There have been three versions of the "I am Legend" story, with Vincent Price, Charleton Heston, and Will Smith in the title roles.

The Charleton Heston version (Omega Man) was in 1971, in Los Angeles....

Vincent Price did the Last Man on Earth in 1964 set in Los Angeles, although it was filmed in Italy.

Will Smith did I am Legend in 2007, set in NYC.

IMDB has all the info....